![]() Low MCV values should be investigated to determine if iron replacement therapy is indicated. The MCV is a useful screening tool to detect iron deficiency and hemoglobinopathy. Pagophagia was defined as compulsive and repeated ingestion of at least. All 81 patients with iron deficiency anemia defined as hemoglobin <12.0 g/dl and ferritin level <12 ng/ml were interviewed about their habits of eating ice or other non-food substances. Hemoglobinopathy is also commonly present but may not be easily recognized in the setting of iron deficiency. The relationship between pagophagia (ice pica) and iron deficiency anemia was studied. Iron deficiency is present in the majority of apheresis donors with repeatedly low MCV values and Hb levels of 12.5 g/dL or more. Hemoglobinopathy without concomitant iron deficiency was found in the remaining 36%. ![]() Iron deficiency was present in 64% 49% had isolated iron deficiency and 15% had iron deficiency plus hemoglobinopathy. ![]() In a 19-month period, 33 of 1162 apheresis donors had low MCV values. Alpha thalassemia trait was presumed if the red blood cell (RBC) count was elevated, no variant Hbs were detected, and the iron studies were within normal ranges. Beta chain Hb variants were determined by Hb electrophoresis. Iron deficiency was defined as a ferritin value below the reference range. Donors with a MCV of less than 80 fL were evaluated by CBC, iron studies (ferritin, serum iron, transferrin, percentage of transferrin saturation), and hemoglobin (Hb) electrophoresis. Predonation samples for CBC were obtained from 1162 consecutive apheresis donors. The etiology of a low MCV in a healthy apheresis donor population was assessed. Low red blood cell mean corpuscular volume (MCV) values (& amp amp amp amp amp lt 80 fL) in the presence of an acceptable hemoglobin (Hb & amp amp amp amp amp gt or=12.5 g/dL) could be due to iron deficiency or hemoglobinopathy. Apheresis donors are routinely evaluated with a complete blood count (CBC).
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